There had been talk before the vote that her dominant European People’s Party might consider talking to the two right-wing groups that house the far right.
But she made clear her only allies would be the Socialists & Democrats and the liberal Renew group that includes Mr Macron’s party.
Germany’s opposition conservatives were always going to come out on top, and they scored an impressive 30% of the vote.
But for Chancellor Olaf Scholz’s SPD party this was the worst ever result in a European election, coming third behind the far-right Alternative for Germany (AfD).
The AfD has endured a slew of scandals involving espionage, foreign interference and allegations of Nazi sympathies, and yet its support still held up.
“After all the prophecies of doom, after the barrage of the last few weeks, we are the second strongest force. And I’m telling you, the only way is up,” said co-leader Alice Weidel.